Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

The lung is an architecturally complex organ comprising a heterogeneous mixture of various
epithelial and mesenchymal lineages. We use single-cell RNA sequencing and signaling …

WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …

The lung is the primary site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)-induced immunopathology whereby the virus enters the host cells by binding to …

Chronic lung diseases represent a major public health problem with only limited therapeutic
options. An important unmet need is to identify compounds and drugs that target key …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One
main pathological feature of COPD is the loss of functional alveolar tissue without adequate …