The emerging antioxidant paradigm of mesenchymal stem cell therapy

R Stavely, K Nurgali - Stem Cells Translational Medicine, 2020 - academic.oup.com
Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for
the treatment of diverse diseases, with many promising outcomes achieved in animal …

Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives

X Liang, Y Ding, Y Zhang, HF Tse… - Cell …, 2014 - journals.sagepub.com
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Y Zhou, H Xu, W Xu, B Wang, H Wu, Y Tao… - Stem cell research & …, 2013 - Springer
Introduction Administration of bone marrow mesenchymal stem cells (MSCs) or secreted
microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles …

Adipose tissue‐derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis

A Eirin, XY Zhu, JD Krier, H Tang, KL Jordan… - Stem …, 2012 - academic.oup.com
Reno‐protective strategies are needed to improve renal outcomes in patients with
atherosclerotic renal artery stenosis (ARAS). Adipose tissue‐derived mesenchymal stem …

Cell-based therapy for acute organ injury: preclinical evidence and ongoing clinical trials using mesenchymal stem cells

A Monsel, Y Zhu, S Gennai, Q Hao, J Liu, JW Lee - Anesthesiology, 2014 - pubs.asahq.org
Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or
brain. Genomic, proteomic, and metabolomic approaches highlight common injury …

From AKI to CKD: maladaptive repair and the underlying mechanisms

Z Wang, C Zhang - International journal of molecular sciences, 2022 - mdpi.com
Acute kidney injury (AKI) is defined as a pathological condition in which the glomerular
filtration rate decreases rapidly over a short period of time, resulting in changes in the …

Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance

J Huang, Y Kong, C Xie, L Zhou - Stem Cell Research & Therapy, 2021 - Springer
Renal failure has a high prevalence and is becoming a public health problem worldwide.
However, the renal replacement therapies such as dialysis are not yet satisfactory for its …

Mesenchymal stem cells and the lung

K Sinclair, ST Yerkovich, DC Chambers - Respirology, 2013 - Wiley Online Library
Mesenchymal stem cells (MSC) are a population of tissue‐resident adult progenitor cells
that were originally identified in bone marrow, but have now been identified in many organs …

[HTML][HTML] In a Phase 1a escalating clinical trial, autologous mesenchymal stem cell infusion for renovascular disease increases blood flow and the glomerular filtration …

A Abumoawad, A Saad, CM Ferguson, A Eirin… - Kidney international, 2020 - Elsevier
Atherosclerotic renovascular disease (ARVD) reduces tissue perfusion and eventually leads
to loss of kidney function with limited therapeutic options. Here we describe results of Phase …

The anti-inflammatory, anti-oxidative, and anti-apoptotic benefits of stem cells in acute ischemic kidney injury

KH Lee, WC Tseng, CY Yang, DC Tarng - International journal of …, 2019 - mdpi.com
Ischemia-reperfusion injury (IRI) plays a significant role in the pathogenesis of acute kidney
injury (AKI). The complicated interaction between injured tubular cells, activated endothelial …