Managing women of childbearing age with chronic myeloid leukemia: safety and treatment considerations

HF Robertson, MJ Buckton… - Expert Review of …, 2023 - Taylor & Francis
Introduction TKIs are paradigmatic in CML management and offer patients the prospect of a
normal life expectancy. As a consequence, the focus of both the clinician and patient has …

Perspectives on drug development for the treatment of chronic myeloid leukemia in pregnant patients and patients who are breastfeeding

JE Cortes, E Abruzzese, EH Cardonick… - Clinical Cancer …, 2024 - AACR
Tyrosine kinase inhibitors (TKI) have improved the outcome and life expectancy of patients
with chronic myeloid leukemia (CML). Patients are diagnosed with CML at younger ages …

Chronic myeloid leukemia diagnosed in pregnancy: management and outcome of 87 patients reported to the European LeukemiaNet international registry

E Chelysheva, J Apperley, A Turkina, MA Yassin… - Leukemia, 2024 - nature.com
The management of chronic myeloid leukemia (CML) diagnosed during pregnancy is a rare
and challenging situation. We report the treatment and outcome of 87 cases diagnosed in …

Treatment of CML in pregnancy

HF Robertson, JF Apperley - Hematology, 2022 - ashpublications.org
Since the introduction of tyrosine kinase inhibitors (TKIs) at the beginning of the millennium,
the outlook for patients with chronic myeloid leukemia (CML) has improved remarkably. As …

Fertility and pregnancy in chronic myeloid leukemia: real-world experience from an Indian tertiary care institution

PS Malik, RK Sahoo, S Sharawat, M Singh, V Garg… - Annals of …, 2023 - Springer
Chronic myeloid leukemia (CML) management during pregnancy is challenging. In this
retrospective study, hospital records of CML patients treated between 2000 and 2021 were …

Physiologically Based Pharmacokinetic Modeling of Nilotinib for Drug‐Drug Interactions, Pediatric Patients, and Pregnancy and Lactation

XI Liu, R Leong, GJ Burckart… - The Journal of Clinical …, 2024 - Wiley Online Library
Nilotinib is a second‐generation BCR‐ABL tyrosine kinase inhibitor for the treatment of
Philadelphia chromosome‐positive chronic myeloid leukemia in both adult and pediatric …

Therapeutic drug monitoring of imatinib–how far are we in the leukemia setting?

AS Buhl Rasmussen, CL Andersen… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Tyrosine kinase inhibitors (TKIs) have revolutionized survival rates
of chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute …

Landscape and Regulatory Perspective on Oncology Drugs in Pregnancy

R Leong, M Grimstein, P DeMaria… - The Journal of …, 2023 - Wiley Online Library
Cancers affecting pregnant women include breast cancer, melanoma, thyroid cancer,
cervical cancer, lymphomas, and leukemias. The medical management of cancer during …

SOHO State of the Art Updates and Next Questions|| Chronic Myeloid Leukemia and Pregnancy:“Per Aspera Ad Astra”

E Abruzzese, MM Trawinska, P De Fabritiis… - … Myeloma and Leukemia, 2023 - Elsevier
Chronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic
disorder that can be treated with targeted drugs and allows survival expectations …

Acute leukemias in pregnant women: Results of a retrospective study at a local tertiary‐care hospital in Japan

S Kobayashi, K Biyajima, S Matsuzawa, K Sakai… - …, 2023 - Wiley Online Library
Leukemia may rarely develop in a woman during pregnancy, posing clinical challenges to
the patient, fetus, family, and medical staff managing malignancy and pregnancy. We …