For three decades, the US Public Health Service has recommended that all persons capable
of becoming pregnant consume 400 μg/day of folic acid (FA) to prevent neural tube defects …

Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord
involvement. The most clinically significant subtype is myelomeningocele (open spina …

Human spinal-cord-like tissues induced from human pluripotent stem cells are typically
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …

Importance Neural tube defects are among the most common congenital malformations in
the US, with an estimated 3000 pregnancies affected each year. Many of these neural tube …

Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth
defects of the central nervous system that originate during embryonic development when the …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between
1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic …

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to read through again again in the future. Its been printed in an exceptionally basic way in …

Importance Neural tube defects are among the most common congenital anomalies in the
United States. Periconceptional folic acid supplementation is a primary care–relevant …

Objective To determine an optimal population red blood cell (RBC) folate concentration for
the prevention of neural tube birth defects. Design Bayesian model. Setting Data from two …