Cognitive dysfunction is core to schizophrenia, and remains poorly treated by existing
therapies. A prominent hypothesis suggests that many symptoms arise from N-methyl-d …

The shift in control from dorsomedial to dorsolateral striatum during skill and habit formation
has been well established, but whether striatal subregions orchestrate this shift …

Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal
cognitive performance. Despite the fact that many have studied how ACh affects neuronal …

This textbook focuses on the relationship between physical exercise and cognition, a very
timely and important topic with major theoretical and practical implications for a number of …

More than one-third of all people are estimated to experience mild to severe cognitive
impairment as they age. Acetylcholine (ACh) levels in the brain diminish with aging, and …

Background Premature responding is a form of motor impulsivity that preclinical evidence
has shown to predict compulsive drug seeking but has not yet been studied in humans. We …

Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …

Nicotine withdrawal is associated with deficits in neurocognitive function including sustained
attention, working memory, and response inhibition. Several convergent lines of evidence …

The interaction of drugs with biologic targets is a critical area of research, particularly for the
development of medications to treat substance use disorders. In addition to understanding …

Drug addiction is widely recognized to afflict some but not all individuals by virtue of
underlying risk markers and traits involving multifaceted interactions between polygenic and …