Cachexia is a devastating, multifactorial and often irreversible systemic syndrome
characterized by substantial weight loss (mainly of skeletal muscle and adipose tissue) that …

Cancer cachexia is a complex multifaceted syndrome involving functional impairment and
changes in body composition that cannot be reversed by nutritional support. Cancer …

Each year, new drugs are introduced to the market, representing structures that have affinity
for biological targets implicated in human diseases and conditions. These new chemical …

Background The prevalence of breast cancer and its mortality rate are increasing rapidly
among women worldwide. On other hand, the courses of chemotherapy as the main …

Cancer cachexia is defined as unintentional weight loss secondary to neoplasia and is
associated with poor prognosis and outcomes. Cancer cachexia associated weight loss …

Simple Summary This study compared mirtazapine with megestrol in the management of
cancer-related anorexia–cachexia syndrome in patients with advanced cancer. This is a …

Cancer-associated cachexia occurs in 50% to 80% of cancer patients and is responsible for
20% to 30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and …

There is no consensus on the optimal endpoint (s) in cancer cachexia trials. Endpoint
variation is an obstacle when comparing interventions and their clinical value. The aim of …

Introduction Cancer cachexia is a multifactorial metabolic syndrome associated with a
pathophysiology intertwined with increased inflammatory response, anorexia, metabolic …

Cancer treatment still encounters challenges, such as side effects and drug resistance. The
tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence …