The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

Tight junctions play a major role in maintaining the integrity and impermeability of the
intestinal barrier. As such, they act as an ideal target for pathogens to promote their …

The intestinal barrier, which primarily consists of a mucus layer, an epithelial barrier, and a
gut vascular barrier, has a crucial role in health and disease by facilitating nutrient …

Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is
characterized by the damage of mucosal epithelium and destruction of the intestinal …

Bark protects the tree against environmental insults. Here, we analyzed whether this
defensive strategy could be utilized to broadly enhance protection against colitis. As a proof …

Inflammatory bowel disease (IBD) is a complex disease characterized by relapsing episodes
of inflammation of the colonic mucosa. Research into IBD suggests that this disease …

The gastrointestinal tract (GIT) is colonized by a broad spectrum of microorganism, of which
bacteria are especially recognized for the health effects they exert. However insight in the …

The aryl hydrocarbon receptor (AHR) is widely expressed in immune and non-immune cells
of the gut and its activation has been correlated to the outcome of inflammatory bowel …

Abstract Nrf2 (nuclear factor erythroid 2-related factor 2) is a stress-responsive transcription
factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the …

Listeria monocytogenes is a food‐borne bacterium that causes gastroenteritis, meningitis, or
abortion. L. monocytogenes induces its internalization (entry) into human cells and either …