Crosstalk between PI3K/AKT/mTOR and WNT/β-Catenin signaling in GBM-Could combination therapy checkmate the collusion?

SD Precilla, I Biswas, SS Kuduvalli, TS Anitha - Cellular Signalling, 2022 - Elsevier
Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …

Wnt signaling inhibitors and their promising role in tumor treatment

N Pećina-Šlaus, S Aničić, A Bukovac… - International Journal of …, 2023 - mdpi.com
In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt
signaling pathway has been recognized as a promising target. The altered functioning of the …

Systems biomarkers for papillary thyroid cancer prognosis and treatment through multi-omics networks

G Gulfidan, M Soylu, D Demirel, HBC Erdonmez… - Archives of Biochemistry …, 2022 - Elsevier
The identification of biomolecules associated with papillary thyroid cancer (PTC) has upmost
importance for the elucidation of the disease mechanism and the development of effective …

The interplay of dysregulated pH and electrolyte imbalance in cancer

KO Alfarouk, SBM Ahmed, A Ahmed, RL Elliott… - Cancers, 2020 - mdpi.com
Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a
combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons …

[HTML][HTML] Autophagy modulators in coronavirus diseases: a double strike in viral burden and inflammation

RCMC Silva, JS Ribeiro, GPD da Silva… - Frontiers in Cellular …, 2022 - frontiersin.org
Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical
medical importance are characterized by highly inflammatory pathophysiology, involving …

Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal

TH Lee, JL Chen, PS Liu, MM Tsai, SJ Wang… - Journal of …, 2020 - Springer
Background Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one
of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced …

Countering triple negative breast cancer via impeding Wnt/β-catenin signaling, a phytotherapeutic approach

L Arzi, H Mollaei, R Hoshyar - Plants, 2022 - mdpi.com
Triple negative breast cancer (TNBC) is characterized as a heterogeneous disease with
severe malignancy and high mortality. Aberrant Wnt/β-catenin signaling is responsible for …

Unraveling the Aquaporin-3 inhibitory effect of rottlerin by experimental and computational approaches

I Paccetti-Alves, MSP Batista, C Pimpão… - International Journal of …, 2023 - mdpi.com
The natural polyphenolic compound Rottlerin (RoT) showed anticancer properties in a
variety of human cancers through the inhibition of several target molecules implicated in …

A review of the chemistry and biological activities of natural colorants, dyes, and pigments: challenges, and opportunities for food, cosmetics, and pharmaceutical …

A Pasdaran, M Zare, A Hamedi… - Chemistry & …, 2023 - Wiley Online Library
Natural pigments are important sources for the screening of bioactive lead compounds. This
article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from …

Predicting Novel Drug Candidates for Pancreatic Neuroendocrine Tumors via Gene Signature Comparison and Connectivity Mapping

Y Xiao, G Xu, JM Cloyd, S Du, Y Mao… - Journal of Gastrointestinal …, 2022 - Elsevier
Introduction There is a paucity of effective treatment options for advanced pancreatic
neuroendocrine tumors (pNETs). Genome-wide analyses may allow for potential drugs to be …