Crosstalk between PI3K/AKT/mTOR and WNT/β-Catenin signaling in GBM-Could combination therapy checkmate the collusion?
Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …
Wnt signaling inhibitors and their promising role in tumor treatment
In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt
signaling pathway has been recognized as a promising target. The altered functioning of the …
signaling pathway has been recognized as a promising target. The altered functioning of the …
Systems biomarkers for papillary thyroid cancer prognosis and treatment through multi-omics networks
G Gulfidan, M Soylu, D Demirel, HBC Erdonmez… - Archives of Biochemistry …, 2022 - Elsevier
The identification of biomolecules associated with papillary thyroid cancer (PTC) has upmost
importance for the elucidation of the disease mechanism and the development of effective …
importance for the elucidation of the disease mechanism and the development of effective …
The interplay of dysregulated pH and electrolyte imbalance in cancer
Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a
combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons …
combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons …
[HTML][HTML] Autophagy modulators in coronavirus diseases: a double strike in viral burden and inflammation
RCMC Silva, JS Ribeiro, GPD da Silva… - Frontiers in Cellular …, 2022 - frontiersin.org
Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical
medical importance are characterized by highly inflammatory pathophysiology, involving …
medical importance are characterized by highly inflammatory pathophysiology, involving …
Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal
TH Lee, JL Chen, PS Liu, MM Tsai, SJ Wang… - Journal of …, 2020 - Springer
Background Upregulation of matrix metalloproteinase-9 (MMP-9) has been indicated as one
of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced …
of the inflammatory biomarkers. In the central nervous system (CNS), the MMP-9 is induced …
Countering triple negative breast cancer via impeding Wnt/β-catenin signaling, a phytotherapeutic approach
L Arzi, H Mollaei, R Hoshyar - Plants, 2022 - mdpi.com
Triple negative breast cancer (TNBC) is characterized as a heterogeneous disease with
severe malignancy and high mortality. Aberrant Wnt/β-catenin signaling is responsible for …
severe malignancy and high mortality. Aberrant Wnt/β-catenin signaling is responsible for …
Unraveling the Aquaporin-3 inhibitory effect of rottlerin by experimental and computational approaches
I Paccetti-Alves, MSP Batista, C Pimpão… - International Journal of …, 2023 - mdpi.com
The natural polyphenolic compound Rottlerin (RoT) showed anticancer properties in a
variety of human cancers through the inhibition of several target molecules implicated in …
variety of human cancers through the inhibition of several target molecules implicated in …
A review of the chemistry and biological activities of natural colorants, dyes, and pigments: challenges, and opportunities for food, cosmetics, and pharmaceutical …
A Pasdaran, M Zare, A Hamedi… - Chemistry & …, 2023 - Wiley Online Library
Natural pigments are important sources for the screening of bioactive lead compounds. This
article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from …
article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from …
Predicting Novel Drug Candidates for Pancreatic Neuroendocrine Tumors via Gene Signature Comparison and Connectivity Mapping
Y Xiao, G Xu, JM Cloyd, S Du, Y Mao… - Journal of Gastrointestinal …, 2022 - Elsevier
Introduction There is a paucity of effective treatment options for advanced pancreatic
neuroendocrine tumors (pNETs). Genome-wide analyses may allow for potential drugs to be …
neuroendocrine tumors (pNETs). Genome-wide analyses may allow for potential drugs to be …