Malaria vaccines: a new era of prevention and control

PE Duffy, JP Gorres, SA Healy, M Fried - Nature Reviews Microbiology, 2024 - nature.com
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Pre-erythrocytic malaria vaccines: RTS, S, R21, and beyond

EA Hammershaimb, AA Berry - Expert Review of Vaccines, 2024 - Taylor & Francis
Malaria is one of the oldest known human diseases, and the Plasmodium genus of parasites
has plagued vertebrates for millions of years. Although five Plasmodium species infect …

Models of Protective Immunity against Schistosomes: Implications for Vaccine Development

RA Wilson - Pathogens, 2023 - mdpi.com
After many decades of research, a schistosome vaccine still looks to be a distant prospect.
These helminths can live in the human bloodstream for years, even decades, surrounded by …

Plasmodium falciparum merozoite surface protein 1 as asexual blood stage malaria vaccine candidate

R Thomson-Luque, TC Stabler, K Fürle… - Expert Review of …, 2024 - Taylor & Francis
Introduction Malaria represents a public health challenge in tropical and subtropical regions,
and currently deployed control strategies are likely insufficient to drive elimination of malaria …

Hepatocytes and the art of killing Plasmodium softly

C Marques-da-Silva, C Schmidt-Silva, SP Kurup - Trends in Parasitology, 2024 - cell.com
The Plasmodium parasites that cause malaria undergo asymptomatic development in the
parenchymal cells of the liver, the hepatocytes, prior to infecting erythrocytes and causing …

[HTML][HTML] Implementation of a randomized, placebo-controlled trial of live attenuated malaria sporozoite vaccines in an Indonesian military study population

K Indrihutami, K Chand, R Fahmia… - The American Journal …, 2024 - ncbi.nlm.nih.gov
Malaria eradication efforts prioritize safe and efficient vaccination strategies, although none
with high-level efficacy against malaria infection are yet available. Among several vaccine …

A new landscape for malaria vaccine development

AJ Laurenson, MB Laurens - PLoS Pathogens, 2024 - journals.plos.org
On October 6, 2021, the World Health Organization (WHO) recommended the first vaccine
against malaria to prevent Plasmodium falciparum malaria in children living in areas with …

Determine the enzymatic kinetic characteristics of CYP3A4 variants utilizing artemether-lumefantrine

X Zhang, Q Li, Q Zhou, Y Li, J Li, L Jin, S Li… - Food and Chemical …, 2023 - Elsevier
Artemether-lumefantrine is an artemisinin-based combination therapy for the treatment of
malaria, which are primarily metabolized by cytochrome P450 3A4. Therapeutic difference …

A paradigm for Africa-centric vaccine development in Equatorial Guinea

PF Billingsley, TL Richie, S Abdulla, MO Ayekaba… - Trends in …, 2024 - cell.com
Abstract The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term
African government and international energy industry investment, plus novel partnerships …