Opsonins and dysopsonins of nanoparticles: facts, concepts, and methodological guidelines

E Papini, R Tavano, F Mancin - Frontiers in immunology, 2020 - frontiersin.org
Understanding the effects mediated by a set of nanoparticle (NP)-bound host biomolecules,
often indicated with the umbrella term of NP corona, is essential in nanomedicine …

The role of protein corona on nanodrugs for organ-targeting and its prospects of application

S Wang, J Zhang, H Zhou, YC Lu, X Jin, L Luo… - Journal of Controlled …, 2023 - Elsevier
Nowadays, nanodrugs become a hotspot in the high-end medical field. They have the ability
to deliver drugs to reach their destination more effectively due to their unique properties and …

The viral protein corona directs viral pathogenesis and amyloid aggregation

K Ezzat, M Pernemalm, S Pålsson, TC Roberts… - Nature …, 2019 - nature.com
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which
significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses …

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

FM Kashkooli, M Soltani, M Souri, C Meaney… - Nano Today, 2021 - Elsevier
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

Nanotechnology in the diagnosis and treatment of lung cancer

AM Cryer, AJ Thorley - Pharmacology & therapeutics, 2019 - Elsevier
Lung cancer is an umbrella term for a subset of heterogeneous diseases that are collectively
responsible for the most cancer-related deaths worldwide. Despite the tremendous progress …

Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across …

G Vergauwen, J Tulkens, C Pinheiro… - Journal of …, 2021 - Wiley Online Library
Separating extracellular vesicles (EV) from blood plasma is challenging and complicates
their biological understanding and biomarker development. In this study, we fractionate …

Targeting strategies for the combination treatment of cancer using drug delivery systems

J Kydd, R Jadia, P Velpurisiva, A Gad, S Paliwal, P Rai - Pharmaceutics, 2017 - mdpi.com
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy
treatment—due to the hostile tumor microenvironment—that create a significant challenge …

Nanoparticles for local delivery of siRNA in lung therapy

M Kubczak, S Michlewska, M Bryszewska… - Advanced Drug Delivery …, 2021 - Elsevier
An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide
delivery into the lung is presented in this review, with a special focus on lung cancer. Due to …

Unveiling the molecular structure of pulmonary surfactant corona on nanoparticles

Q Hu, X Bai, G Hu, YY Zuo - ACS nano, 2017 - ACS Publications
The growing risk of human exposure to airborne nanoparticles (NPs) causes a general
concern on the biosafety of nanotechnology. Inhaled NPs can deposit in the deep lung at …

[HTML][HTML] Pulmonary surfactant and nanocarriers: Toxicity versus combined nanomedical applications

A Hidalgo, A Cruz, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of
breathing, which coats and stabilizes the whole respiratory surface and possesses …