Background We aimed to assess whether interferon-γ release assays (IGRAs) can predict
the development of active tuberculosis and whether the predictive ability of these tests is …

Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent
infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for …

Importance Latent tuberculosis infection (LTBI) can progress to active tuberculosis disease,
causing morbidity and mortality. Objective To review the evidence on benefits and harms of …

Whole blood transcriptional signatures distinguishing active tuberculosis patients from
asymptomatic latently infected individuals exist. Consensus has not been achieved …

Background Given the current lack of effective vaccines against TB, the accuracy of
screening tests for determining or excluding latent TB infection (LTBI) is decisive in effective …

Background. The diagnostic value of interferon-γ release assays (IGRAs) for active
tuberculosis in low-and middle-income countries is unclear. Methods. We searched multiple …

Background Prophylactic treatment of individuals with latent Mycobacterium tuberculosis
infection is an essential component of tuberculosis control in some settings. In China, the …

Rationale: Only limited data are available on the predictive value of interferon-γ release
assays for progression from latent tuberculosis infection to active tuberculosis (TB) …

BACKGROUND. The identification and treatment of individuals with tuberculosis (TB) is a
global public health priority. Accurate diagnosis of pulmonary active TB (ATB) disease …

Rationale: IFN-γ release assays (IGRAs) are alternatives to tuberculin skin testing (TST) for
diagnosis of latent tuberculosis infection. Limited data suggest IGRAs may not perform well …