Consideration of the possibility that T lymphocytes might be central to the pathogenesis of
rheumatoid arthritis (RA) first became prominent in the 1980s (1). Only after new approaches …

RECEPTORS Chemokines are small 70 amino acid long soluble proteins that chemoattract
a variety of mononuclear cell types to sites of inflammation or secondary lymphoid organs by …

Rheumatoid arthritis (RA) is characterized by the accumulation of CD4+ memory T cells in
the inflamed synovium. To address the mechanism, we analyzed chemokine receptor …

Objective. To define the immunohistologic features of the synovial membrane (SM) of
patients with psoriatic arthritis (PA) and to compare them with those of an age‐and disease …

Experiments were designed to test the hypothesis that chronic exposure to tumor necrosis
factor alpha (TNF) alters the function of activated T lymphocytes. Pretreatment of tetanus …

Interactions of the tumor necrosis factor superfamily members B lymphocyte stimulator
(BLyS) and a proliferation-inducing ligand (APRIL) with their receptors—transmembrane …

Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with
massive T cell infiltration into the synovium. The accumulated T cells express type 1 …

CD40 ligand (CD40-L), a member of the tumor necrosis family of transmembrane
glycoproteins, is rapidly and transiently expressed on the surface of recently activated CD4+ …

Objective To determine the cytokine profile of CD4+ T cells in the synovial tissue (ST) of
rheumatoid arthritis (RA) patients at the single‐cell level. Methods Unseparated ST cells and …

Between January 1991 and January 1993, 265 patients who fulfilled the CDC criteria of the
working case definition of Chronic Fatigue Syndrome (CFS) have been observed at our …