In addition to its function as a tumour suppressor, p53 is also involved in an increasing
number of pathology associated with aging. Several activities of p53 appear contribute to its …

Cytokines play several roles in developing and/or reinforcing premature cellular senescence
of young cells. One such cytokine, interleukin-6 (IL-6), regulates senescence in some …

ABSTRACT A hallmark of cellular senescence is proliferation-like activity of growth-
promoting pathways (such as mTOR and MAPK) in non-proliferating cells. When the cell …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Numerous observations indicate a strong link between chronic inflammation and cancer.
This link is supported by substantial experimental evidence indicating mutual negative …

During cell cycle arrest caused by contact inhibition (CI), cells do not undergo senescence,
thus resuming proliferation after replating. The mechanism of senescence avoidance during …

Chronic inflammation is a major cancer predisposition factor. Constitutive activation of the
inflammation-driving NF-κB pathway commonly observed in cancer or developed in normal …

Abstract Activation of PI3K/Akt/mTOR (mechanistic target of rapamycin) signaling cascade
has been shown in tumorigenesis of numerous malignancies including glioblastoma (GB) …

Cellular senescence happens in 2 steps: cell cycle arrest followed, or sometimes preceded,
by gerogenic conversion (geroconversion). Geroconvesrion is a form of growth, a futile …

Cellular senescence has been implicated in normal aging, tissue homeostasis, and tumor
suppression. Although p53 has been shown to be a central mediator of cellular senescence …