[HTML][HTML] Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma
V Bevelacqua, Y Bevelacqua, S Candido… - Oncotarget, 2012 - ncbi.nlm.nih.gov
NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins
and platelet-derived growth factor receptor, that are essential for intercellular …
and platelet-derived growth factor receptor, that are essential for intercellular …
CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion
OV Leontieva, MV Blagosklonny - Cell cycle, 2013 - Taylor & Francis
CDKN1A (p21) and CDKN2A (p16) inhibit CDK4/6, initiating senescence. According to our
view on senescence, the role of p21 and p16 is to cause cell cycle arrest, whereas MTOR …
view on senescence, the role of p21 and p16 is to cause cell cycle arrest, whereas MTOR …
[HTML][HTML] Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia …
AM Martelli, F Chiarini, C Evangelisti, A Cappellini… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Abstract Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR)
are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction …
are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction …
Pharmacologic activation of p53 by small-molecule MDM2 antagonists
H Shen, CG Maki - Current pharmaceutical design, 2011 - ingentaconnect.com
Restoring p53 activity by inhibiting the interaction between p53 and MDM2 represents an
attractive approach for cancer therapy. To this end, a number of small-molecule p53-MDM2 …
attractive approach for cancer therapy. To this end, a number of small-molecule p53-MDM2 …
Weak p53 permits senescence during cell cycle arrest
OV Leontieva, AV Gudkov, MV Blagosklonny - Cell cycle, 2010 - Taylor & Francis
Cell cycle arrest coupled with hyper-active mTOR leads to cellular senescence. While
arresting cell cycle, high levels of p53 can inhibit mTOR (in some cell lines), thus causing …
arresting cell cycle, high levels of p53 can inhibit mTOR (in some cell lines), thus causing …
mTORC1 and p53: clash of the gods?
P Hasty, ZD Sharp, TJ Curiel, J Campisi - Cell Cycle, 2013 - Taylor & Francis
A balance must be struck between cell growth and stress responses to ensure that cells
proliferate without accumulating damaged DNA. This balance means that optimal cell …
proliferate without accumulating damaged DNA. This balance means that optimal cell …
Filling the gap after CDK4/6 inhibitors: novel endocrine and biologic treatment options for metastatic hormone receptor positive breast cancer
A Mittal, C Molto Valiente, F Tamimi, I Schlam… - Cancers, 2023 - mdpi.com
Simple Summary There are limited treatment options beyond chemotherapy for patients with
hormone receptor positive metastatic breast cancer after progression on first line therapy …
hormone receptor positive metastatic breast cancer after progression on first line therapy …
[HTML][HTML] Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression
OV Leontieva, MV Blagosklonny - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
In yeast, chronological senescence (CS) is defined as loss of viability in stationary culture.
Although its relevance to the organismal aging remained unclear, yeast CS was one of the …
Although its relevance to the organismal aging remained unclear, yeast CS was one of the …
Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G …
Y Zhu, W He, X Gao, B Li, C Mei, R Xu, H Chen - Scientific reports, 2015 - nature.com
Gefitinib (Gef) provides clinical benefits to non-small cell lung cancer (NSCLC) patients with
activating EGFR mutations. However, acquired resistance (AR) is a major obstacle to …
activating EGFR mutations. However, acquired resistance (AR) is a major obstacle to …
Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
A Salminen, K Kaarniranta - Cellular signalling, 2011 - Elsevier
The stress-activated signaling pathways, p53 and NF-κB, have a major role in the regulation
of cellular senescence and organismal aging. These ancient signaling networks display …
of cellular senescence and organismal aging. These ancient signaling networks display …