Aging is characterized by a progressive decline in organism functions due to the impairment
of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular …

Prostate cancer (PCa) is a cancer that occurs in the prostate with high morbidity and
mortality. Danggui Beimu Kushen Wan (DBKW) is a classic formula for patients with difficult …

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6iss) are widely used in first-line metastatic
breast cancer. For patients with progression under CDK4/6is, there is currently no standard …

The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to
regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function …

After several years of extensive research, the main cause of aging is yet elusive. There are
some theories about aging, such as stem cell aging, senescent cells accumulation, and …

Common cancer is an age-related disease. Slow aging is associated with reduced and
delayed carcinogenesis. Calorie restriction (CR), the most studied anti-aging intervention …

MYCN amplification is a major biomarker of poor prognosis, occurring in 25–30% of
neuroblastomas. MYCN has contradictory roles in promoting cell growth and sensitizing …

In proliferating cells, mTOR is active and promotes cell growth. When the cell cycle is
arrested, then mTOR converts reversible arrest to senescence (geroconversion). Rapamycin …

The TOR (target of rapamycin) pathway is involved in aging in diverse organisms from yeast
to mammals. We have previously demonstrated in human and rodent cells that mTOR …

When the cell cycle becomes arrested, MTOR (mechanistic Target of Rapamycin) converts
reversible arrest into senescence (geroconversion). Hyperexpression of cyclin D1 is a …