The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Today, it is widely accepted that proteins that lack highly defined globular three-dimensional
structures, termed IDPs (intrinsically disordered proteins), play key roles in myriad biological …

The DNA polymerase delta processivity factor Proliferating Cell Nuclear Antigen (PCNA)
promotes the DNA damage-induced degradation of the replication initiation factor Cdt1 via …

The Restriction Point was originally defined as the moment that cells commit to the cell cycle
and was later suggested to coincide with hyperphosphorylation of the retinoblastoma protein …

Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although
seemingly discrete and unrelated mechanisms, these pathways can now be shown to be …

The proteasome is the main proteolytic machinery of the cell and constitutes a recognized
drugable target, in particular for treating cancer. It is involved in the elimination of misfolded …

During the G1/S transition, p21 proteolysis is mediated by Skp2; however, p21
reaccumulates in G2 and is degraded again in prometaphase. How p21 degradation is …

p21 was originally described as functioning as a cell cycle regulator via inhibition of both
cyclin-dependent kinases and processive DNA replication. Nowadays it is recognised to …

Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (CDK2), is central to the initiation
of DNA replication at the G1/S checkpoint. Tight temporal control of cyclin E is essential to …

The liver acts as a hub for metabolic reactions to keep a homeostatic balance during
development and growth. The process of liver cancer development, although poorly …