Chronic unresolving inflammation is emerging as a key underlying pathological feature of
many if not most diseases ranging from autoimmune conditions to cardiometabolic and …

The Nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3
(NLRP3), a member of the nucleotide-binding oligomerization domain (NOD) like receptors …

The comprehensive anabolic effects of insulin throughout the body, in addition to the control
of glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation …

Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic
retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases …

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Cardiovascular diseases (CVD) are the leading cause of death worldwide. Since the
establishment of the “lipid hypothesis”, according to which, cholesterol level is directly …

Aberrant NLRP3 activation has been implicated in the pathogenesis of numerous
inflammation-associated diseases. However, no small molecular inhibitor that directly …

Cyclophosphamide has drastically enhanced the expectancy and quality of life of cancer
patients. However, it is accompanied by diverse neurological complications which are …

We are witnessing the globalization of a specific type of arteriosclerosis with rising
prevalence, incidence and an overall cardiovascular disease burden. Currently …