Epstein–Barr virus: To be a trigger of autoimmune glial fibrillary acidic protein astrocytopathy?

XL Li, JY Wang, LK Li, CL Yang… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel
autoimmune disease of central nervous system (CNS). It is unclear whether Epstein–Barr …

B cells going viral in the CNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis

A Cardani‐Boulton, BT Boylan… - Immunological …, 2022 - Wiley Online Library
A diverse number of DNA and RNA viruses have the potential to invade the central nervous
system (CNS), causing inflammation and injury to cells that have a limited capacity for repair …

Studying the interactions of U24 from HHV-6 in order to further elucidate its potential role in MS

KS Pi, D Bortolotti, Y Sang, G Schiuma, S Beltrami… - Viruses, 2022 - mdpi.com
A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role
in multiple sclerosis (MS). Three possible hypotheses have been investigated:(1) U24 from …

Plasma IgG aggregates as biomarkers for multiple sclerosis

W Zhou, M Graner, C Beseler, T Domashevich… - Clinical …, 2023 - Elsevier
We recently reported that multiple sclerosis (MS) plasma contains IgG aggregates and
induces complement-dependent neuronal cytotoxicity (Zhou et al., 2023). Using ELISA, we …

Viral proteins with PxxP and PY motifs may play a role in multiple sclerosis

KS Pi, Y Sang, SK Straus - Viruses, 2022 - mdpi.com
Multiple sclerosis (MS) is a debilitating disease that arises from immune system attacks to
the protective myelin sheath that covers nerve fibers and ensures optimal communication …

The neuroimmunology of multiple sclerosis: fictions and facts

AR Pachner - Frontiers in Neurology, 2022 - frontiersin.org
There have been tremendous advances in the neuroimmunology of multiple sclerosis over
the past five decades, which have led to improved diagnosis and therapy in the clinic …

Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases

X Xu, Y Han, B Zhang, Q Ren, J Ma, S Liu - Cell Communication and …, 2024 - Springer
Abnormal inflammatory states in the brain are associated with a variety of brain diseases.
The dynamic changes in the number and function of immune cells in cerebrospinal fluid …

Gene–environment interactions: Epstein–Barr virus infection and risk of pediatric-onset multiple sclerosis

A Ziaei, O Solomon, TC Casper… - Multiple Sclerosis …, 2024 - journals.sagepub.com
Background and Objective: Prior Epstein–Barr virus (EBV) infection is associated with an
increased risk of pediatric-onset multiple sclerosis (POMS) and adult-onset multiple …

Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8+ T-Cell Proliferation in Patients With Multiple Sclerosis

G Abbadessa, MT Lepore, S Bruzzaniti… - Neurology …, 2024 - AAN Enterprises
Background and Objectives The role of B cells in the pathogenic events leading to relapsing
multiple sclerosis (R-MS) has only been recently elucidated. A pivotal step in defining this …

Ursolic acid derivative UAOS-Na treats experimental autoimmune encephalomyelitis by immunoregulation and protecting myelin

M Wang, C Gu, Y Yang, L Chen, K Chen, J Du… - Frontiers in …, 2023 - frontiersin.org
Introduction Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central
nervous system (CNS). Ursolic acid (UA) can be used in the MS treatment with anti …