Protein aggregation-inhibition: a therapeutic route from Parkinson's disease to sickle cell anemia
GF Martins, N Galamba - Critical Reviews in Biochemistry and …, 2023 - Taylor & Francis
Protein aggregation is implicated in multiple diseases, so-called proteinopathies, ranging
from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease …
from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease …
Evaluating sheep hemoglobins with MD simulations as an animal model for sickle cell disease
Sickle cell disease (SCD) affects millions worldwide, yet there are few therapeutic options.
To develop effective treatments, preclinical models that recapitulate human physiology and …
To develop effective treatments, preclinical models that recapitulate human physiology and …
The Use of Natural Products in the Treatment of Sickle Cell Disease
RG de Paula, HM Ribeiro, L de Melo Borges… - Revista Brasileira de …, 2024 - Springer
Sickle cell disease is the world's leading inherited genetic hemoglobinopathy, originating
from African peoples, characterized by the presence of more than 50% hemoglobin S in red …
from African peoples, characterized by the presence of more than 50% hemoglobin S in red …
Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease
Sickle cell disease is a missense genetic disorder characterized by the aggregation of deoxy-
HbS into helical fibers that distort erythrocytes into a sickle-like shape. Herein, we …
HbS into helical fibers that distort erythrocytes into a sickle-like shape. Herein, we …
Molecular dynamics of hemoglobin reveals structural alterations and explains the interactions driving sickle cell fibrillation
In sickle cell anemia, deoxyhemoglobin deforms RBCs by forming fibrils inside that
disintegrate on oxygenation. We studied 100 ns long all-atom molecular dynamics (MD) for …
disintegrate on oxygenation. We studied 100 ns long all-atom molecular dynamics (MD) for …
Multiscale MD simulations of wild‐type and sickle hemoglobin aggregation
MO Olagunju, J Loschwitz, OO Olubiyi… - Proteins: Structure …, 2022 - Wiley Online Library
Sickle cell disease is a hemoglobinopathy resulting from a point mutation from glutamate to
valine at position six of the β‐globin chains of hemoglobin. This mutation gives rise to …
valine at position six of the β‐globin chains of hemoglobin. This mutation gives rise to …