Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases

D Li, C Liu - Nature Reviews Neuroscience, 2022 - nature.com
Amyloid proteins, which are considered 'villains' in many neurodegenerative diseases, form
enigmatic pathological strains that underlie disease pathogenesis and progression. Recent …

Neuropathology of autonomic dysfunction in synucleinopathies

EA Coon, JK Cutsforth‐Gregory… - Movement …, 2018 - Wiley Online Library
The synucleinopathies—Parkinson's disease, dementia with Lewy bodies, multiple system
atrophy, and pure autonomic failure—result from distinct patterns of abnormal α‐synuclein …

[HTML][HTML] Autonomic dysfunction in α-synucleinopathies

JJ Mendoza-Velásquez, JF Flores-Vázquez… - Frontiers in …, 2019 - frontiersin.org
The α-synucleinopathies are a group of neurodegenerative diseases characterized by
abnormal accumulation of insoluble α-synuclein in neurons and glial cells, comprising …

α-Synuclein in cutaneous autonomic nerves

N Wang, CH Gibbons, J Lafo, R Freeman - Neurology, 2013 - AAN Enterprises
Objective: To develop a cutaneous biomarker for Parkinson disease (PD). Methods: Twenty
patients with PD and 14 age-and sex-matched control subjects underwent examinations …

Preclinical biomarkers of Parkinson disease

Y Wu, W Le, J Jankovic - Archives of neurology, 2011 - jamanetwork.com
The search for markers of preclinical Parkinson disease (PD) is becoming increasingly
important because pathogenesis-targeted neuroprotective strategies are being developed …

Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

Z Tanei, Y Saito, S Ito, T Matsubara, A Motoda… - Acta …, 2021 - Springer
Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders
characterized by the wide distribution of Lewy bodies and neurites in the central and …

Parkinson disease affects peripheral sensory nerves in the pharynx

L Mu, S Sobotka, J Chen, H Su… - … of Neuropathology & …, 2013 - academic.oup.com
Dysphagia is very common in patients with Parkinson disease (PD) and often leads to
aspiration pneumonia, the most common cause of death in PD. Current therapies are largely …

Primary skin fibroblasts as a model of Parkinson's disease

G Auburger, M Klinkenberg, J Drost, K Marcus… - Molecular …, 2012 - Springer
Parkinson's disease is the second most frequent neurodegenerative disorder. While most
cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) …

Altered pharyngeal muscles in Parkinson disease

L Mu, S Sobotka, J Chen, H Su… - … of Neuropathology & …, 2012 - academic.oup.com
Dysphagia (impaired swallowing) is common in patients with Parkinson disease (PD) and is
related to aspiration pneumonia, the primary cause of death in PD. Therapies that …

Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease

L Mu, S Sobotka, J Chen, H Su… - … of Neuropathology & …, 2013 - academic.oup.com
Parkinson disease (PD) is a neurodegenerative disease primarily characterized by cardinal
motor manifestations and CNS pathology. Current drug therapies can often stabilize these …