The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …

Aging leads to a multitude of changes in the cardiovascular system, including systolic
hypertension, increased central vascular stiffness, and increased pulse pressure. In this …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Background Atrial fibrillation (AF) is mediated by oxidative stress, neurohormonal activation,
and inflammatory activation. Serum uric acid (SUA) is a surrogate marker of oxidative stress …

Background and aims Systemic reviews and meta-analyses suggest hyperuricemia is a
cardiovascular risk factor. The effects of xanthine oxidase inhibitors on cardiac outcomes …

The NO/ONOO-cycle is a primarily local, biochemical vicious cycle mechanism, centered on
elevated peroxynitrite and oxidative stress, but also involving 10 additional elements: NF-κB …

Background: We previously reported increased plasma XO (xanthine oxidase) activity in
patients with resistant hypertension. Increased XO can cause mitochondrial DNA damage …

Although the combined use of hydralazine and isosorbide dinitrate confers important clinical
benefits in patients with heart failure, the underlying mechanism of action is still …

The evolution of the metabolic syndrome in afflicted individuals is, in part, characterized by
the development of a severely pro-oxidant state within the vasculature. It has been …

Background We investigated whether urinary 8-hydroxy-2′-deoxyguanosine (U-8-OHdG),
a marker of oxidative DNA damage, is a prognosticator of cardiovascular-related death in …