Insulin signalling and the regulation of glucose and lipid metabolism
AR Saltiel, CR Kahn - Nature, 2001 - nature.com
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …
Age-related changes in total and regional fat distribution
Aging is associated with progressive changes in total and regional fat distribution that have
negative health consequences. Indeed, a preferential increase in abdominal fat, in particular …
negative health consequences. Indeed, a preferential increase in abdominal fat, in particular …
Skeletal muscle lipid metabolism in exercise and insulin resistance
B Kiens - Physiological reviews, 2006 - journals.physiology.org
Lipids as fuel for energy provision originate from different sources: albumin-bound long-
chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins …
chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins …
Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review
GJ Kemp, M Meyerspeer… - NMR in Biomedicine: An …, 2007 - Wiley Online Library
Abstract 31P MRS offers a unique view of muscle metabolism in vivo, but correct
quantification is important. Inter‐study correlation of estimates of [Pi] and [phosphocreatine …
quantification is important. Inter‐study correlation of estimates of [Pi] and [phosphocreatine …
Whole body fat: content and distribution
Obesity and its co-morbidities, including type II diabetes, insulin resistance and
cardiovascular diseases, have become one of the biggest health issues of present times …
cardiovascular diseases, have become one of the biggest health issues of present times …
Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance‐trained males in a fasted state
LJC Van Loon, R Koopman… - The Journal of …, 2003 - Wiley Online Library
Both stable isotope methodology and fluorescence microscopy were applied to define the
use of intramuscular triglyceride (IMTG) stores as a substrate source during exercise on a …
use of intramuscular triglyceride (IMTG) stores as a substrate source during exercise on a …
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
LJC van Loon, BH Goodpaster - Pflügers Archiv, 2006 - Springer
Numerous studies have reported a strong correlation between intramuscular triacylglycerol
(IMTG) content and insulin resistance. However, the proposed relationship between IMTG …
(IMTG) content and insulin resistance. However, the proposed relationship between IMTG …
Use of intramuscular triacylglycerol as a substrate source during exercise in humans
LJC van Loon - Journal of applied physiology, 2004 - journals.physiology.org
Fat and carbohydrate are the principal substrates that fuel aerobic ATP synthesis in skeletal
muscle. Most endogenous fat is stored as triacylglycerol in subcutaneous and deep visceral …
muscle. Most endogenous fat is stored as triacylglycerol in subcutaneous and deep visceral …
Myocellular triacylglycerol breakdown in females but not in males during exercise
CH Steffensen, C Roepstorff… - American Journal of …, 2002 - journals.physiology.org
The resting content and use of myocellular triacylglycerol (MCTG) during 90 min of
submaximal exercise [60% of peak oxygen uptake (V˙ o 2 peak)] were studied in 21 …
submaximal exercise [60% of peak oxygen uptake (V˙ o 2 peak)] were studied in 21 …
Intramyocellular lipid content in human skeletal muscle
VB Schrauwen‐Hinderling, MKC Hesselink… - …, 2006 - Wiley Online Library
Fat can be stored not only in adipose tissue but also in other tissues such as skeletal
muscle. Fat droplets accumulated in skeletal muscle [intramyocellular lipids (IMCLs)] can be …
muscle. Fat droplets accumulated in skeletal muscle [intramyocellular lipids (IMCLs)] can be …