Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

Background The recent development of metagenomic sequencing makes it possible to
massively sequence microbial genomes including viral genomes without the need for …

Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Efforts to reduce global cancer disparities begin with an understanding of geographic
patterns in cancer incidence, mortality, and prevalence. Using the GLOBOCAN (2002) and …

Background Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the
number of colorectal adenomas in animals and patients with familial adenomatous …

OBJECTIVES: To discuss nonsteroidal anti-inflammatory drugs (NSAIDs), their history,
development, mode of action, toxicities, strategies for the prevention of toxicity, and future …

Background: A recent comprehensive review concluded that additional research is needed
to determine the optimal use of aspirin for cancer prevention. Objective: To assess …

Pre-clinical and clinical data produce mounting evidence that the microbiota is strongly
associated with colorectal carcinogenesis. Dysbiosis may change the course of …

Objective To critically evaluate recent studies that examined determinants of CRC screening
behaviors among average-risk older adults (≥ 50 years) in the United States. Methods A …