Alzheimer's disease (AD) is a progressive neurological condition. The rising prevalence of
AD necessitates the rapid development of efficient therapy options. Despite substantial …

Mammalian flavoenzyme Monoamine oxidase (MAO) resides on the outer mitochondrial
membrane (OMM) and it is involved in the metabolism of different monoamine …

In this study, a molecular docking technique was used to investigate the interactions of
phenelzine (P) and its derivatives, namely N-Nitrosobenzylmethylamine (P4) and [2-(4 …

Hesperetin, a methoxylated flavanone, has numerous biological activities. Access to this
compound is currently restricted by its low abundance in plants, which limits its practical …

Neurological (such as stroke, Alzheimer's, Parkinson's, epilepsy) and neuropsychiatric (such
as autism, migraine, depression, anxiety, stress) disorders continue to be on rising every …

A series of (S)-1-phenyl-3, 4-dihydroisoquinoline-2 (1 H)-carboxamide derivatives was
synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and …

A series of dietary flavonoid acacetin 7-O-methyl ether derivatives were computationally
designed aiming to improve the selectivity and potency profiles against monoamine oxidase …

According to the fusion technique create effective multi‐target‐directed ligands, in this study,
we designed and synthesized a series of benzo [d] thiazol‐2‐yl)‐3‐(pyrrolidin‐1‐yl) or 3 …

Purpose Chronic ethanol exposure causes neurotoxicity and long-term learning and
memory impairment along with hippocampal and frontal cortical dysfunction. Flavonoids …

Diabetes is a persistent metabolic disorder characterized by elevated blood sugar levels,
potentially leading to complications such as diabetic retinopathy, neuropathy, and …