Tremendous biomedical advancements in HIV prevention and treatment have led to
aspirational efforts to end the HIV epidemic. However, this goal will not be achieved without …

In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

Objective To characterize the prevalence and burden of HIV-associated neurocognitive
disorder (HAND) and assess associated factors in the global population with HIV. Methods …

Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

Background Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …

Objective: To evaluate the frequency of HIV-associated neurocognitive disorder (HAND) in
HIV+ individuals and determine whether the frequency of HAND changed over 4 years of …

The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and
mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders …

Background. Human immunodeficiency virus (HIV)-associated neurocognitive disorders
(HAND) can show variable clinical trajectories. Previous longitudinal studies of HAND …