Major depression disorder (MDD) is a neuropsychiatric disorder associated with a high
suicide rate and a higher disability rate than any other disease. Evidence suggests that the …

A class of glial cell, astrocytes, is highly abundant in the central nervous system (CNS). In
addition to maintaining tissue homeostasis, astrocytes regulate neuronal communication …

Glucocorticoid stress hormones are powerful modulators of brain function and can affect
mood and cognitive processes. The hippocampus is a prominent glucocorticoid target and …

Chronic exposure to high circulating levels of glucocorticoids has detrimental effects on
health, including metabolic abnormalities, as exemplified in Cushing's syndrome (CS) …

Astrocytes are essential for maintaining the homeostasis of the central nervous system
(CNS). Astrocytic dysfunction has been implicated in the progression of several …

Long-term exposure to physical and/or psychosocial stress during early life and/or
adolescence increases the risk of psychiatric disorders such as major depressive disorder …

Excess glucocorticoid exposure affects emotional and cognitive brain functions. The extreme
form, Cushing's syndrome, is adequately modelled in the AdKO2. 0 mouse, consequential to …

High-frequency repetitive transcranial magnetic stimulation (rTMS) is a widely used and
effective biological treatment for depression. Although previous studies have shown that …

Depressive disorders are widely debilitating psychiatric disease. Despite the considerable
progress in the field of depression therapy, extensive research spanning many decades has …

Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted
psychiatric disorder that occurs following a stressful or traumatic event or series of events …