The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

The pathological role of reactive gliosis in CNS repair remains controversial. In this study,
using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia …

A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Intracerebral hemorrhage (ICH) is a highly fatal disease with mortality rate of approximately
50%. Oxidative stress (OS) is a prominent cause of brain injury in ICH. Important sources of …

The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …

Microglia are the resident immune cells of the central nervous system that exert diverse roles
in the pathogenesis of ischemic stroke. During the past decades, microglial polarization and …

Neuronal activity creates an intense energy demand that must be met by rapid metabolic
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …