Dementia is a term used to define different brain disorders that affect memory, thinking,
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …

Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles
chemistry during the last decades. Five and six membered ring azaheterocycles are …

Based on previous work, a series of novel 5-(2-hydroxyphenyl)-2-phthalide-3 (3H)-
pyrazolones derivatives were identified as potential multifunctional therapeutic agents for …

A novel strategy for the construction of 2, 2-diacyl spirocyclohexanones 3 has been
demonstrated on the basis of an NHC-catalyzed [3C+ 3C] annulation of potassium 2-oxo-3 …

Alzheimer disease (AD) is characterized by a low level of acetylcholine, beta-amyloid (Aβ)
aggregation and oxidative stress. Donepezil is the core medicine used for the treatment of …

Abstract Phthalazin-1 (2H)-one is a diazaheterobicycle found in a wide variety of synthetic
molecules relevant to several branches of chemistry, including medicinal chemistry. The …

Heterocyclics are the crucial scaffolds present in pharmaceuticals, natural products,
biologically active compounds and agrochemicals. Consequently, the development of …

Alzheimer's Disease (AD) is a multifactorial incurable neurodegenerative disorder. It is
characterized by a decline of cholinergic function in parallel with β-amyloid fibril deposition …

Nowadays, cancer disease seems to be the second most common cause of death
worldwide. Molecular hybridization is a drug design strategy that has provided promising …

A novel class of potential MAO-B inhibitors was designed and synthesized in good yield by
combining the pyridazinone moiety with the dithiocarbamate framework, two relevant …