Artificial intelligence-assisted selection and efficacy prediction of antineoplastic strategies for precision cancer therapy

ZHE Zhang, X Wei - Seminars in Cancer Biology, 2023 - Elsevier
The rapid development of artificial intelligence (AI) technologies in the context of the vast
amount of collectable data obtained from high-throughput sequencing has led to an …

[HTML][HTML] Inflammasome activation in pulmonary arterial hypertension

A Foley, BE Steinberg, NM Goldenberg - Frontiers in Medicine, 2022 - frontiersin.org
Inflammasomes are multi-protein complexes that sense both infectious and sterile
inflammatory stimuli, launching a cascade of responses to propagate danger signaling …

[HTML][HTML] Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

F Khassafi, P Chelladurai, C Valasarajan… - Nature cardiovascular …, 2023 - nature.com
Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension.
Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV …

Serum and pulmonary expression profiles of the activin signaling system in pulmonary arterial hypertension

C Guignabert, L Savale, A Boucly, R Thuillet, L Tu… - Circulation, 2023 - Am Heart Assoc
Background: Activins are novel therapeutic targets in pulmonary arterial hypertension (PAH).
We therefore studied whether key members of the activin pathway could be used as PAH …

[HTML][HTML] GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice

S Sonny, H Yuan, S Chen, MR Duncan, P Chen… - Scientific reports, 2023 - nature.com
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are among the
most common morbidities affecting extremely premature infants who receive oxygen …

TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension

FC Yeh, CN Chen, CY Xie, N Baxan… - European …, 2023 - Eur Respiratory Soc
Extract Growing evidence supports the contention that immune dysregulation and
autoimmunity predispose and contribute to the pathological remodelling that characterise …

[HTML][HTML] Artificial intelligence and cardiovascular risk prediction: all that glitters is not gold

M Chiarito, L Luceri, A Oliva, G Stefanini… - European Cardiology …, 2022 - ncbi.nlm.nih.gov
Artificial intelligence (AI) is a broad term referring to any automated systems that need
'intelligence'to carry out specific tasks. During the last decade, AI-based techniques have …

Association study identified HLA‐DQA1 as a novel genetic risk of systemic lupus erythematosus‐associated pulmonary arterial hypertension

J Qian, Y Chen, X Yang, Q Wang, J Zhao… - Arthritis & …, 2023 - Wiley Online Library
Objective Pulmonary arterial hypertension (PAH) is severe complication of systemic lupus
erythematosus (SLE). However, the genetic signatures of SLE‐associated PAH have not …

[HTML][HTML] The landscape of noncoding RNA in pulmonary hypertension

L Deng, X Han, Z Wang, X Nie, J Bian - Biomolecules, 2022 - mdpi.com
The transcriptome of pulmonary hypertension (PH) is complex and highly genetically
heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs …

[HTML][HTML] An explorative metabolomic analysis of the endothelium in pulmonary hypertension

J Carlsen, HH Henriksen, I Marin de Mas… - Scientific reports, 2022 - nature.com
Pulmonary hypertension (PH) is classified into five clinical diagnostic groups, including
group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease …