Artificial intelligence-assisted selection and efficacy prediction of antineoplastic strategies for precision cancer therapy
ZHE Zhang, X Wei - Seminars in Cancer Biology, 2023 - Elsevier
The rapid development of artificial intelligence (AI) technologies in the context of the vast
amount of collectable data obtained from high-throughput sequencing has led to an …
amount of collectable data obtained from high-throughput sequencing has led to an …
[HTML][HTML] Inflammasome activation in pulmonary arterial hypertension
A Foley, BE Steinberg, NM Goldenberg - Frontiers in Medicine, 2022 - frontiersin.org
Inflammasomes are multi-protein complexes that sense both infectious and sterile
inflammatory stimuli, launching a cascade of responses to propagate danger signaling …
inflammatory stimuli, launching a cascade of responses to propagate danger signaling …
[HTML][HTML] Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension
F Khassafi, P Chelladurai, C Valasarajan… - Nature cardiovascular …, 2023 - nature.com
Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension.
Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV …
Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV …
Serum and pulmonary expression profiles of the activin signaling system in pulmonary arterial hypertension
C Guignabert, L Savale, A Boucly, R Thuillet, L Tu… - Circulation, 2023 - Am Heart Assoc
Background: Activins are novel therapeutic targets in pulmonary arterial hypertension (PAH).
We therefore studied whether key members of the activin pathway could be used as PAH …
We therefore studied whether key members of the activin pathway could be used as PAH …
[HTML][HTML] GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are among the
most common morbidities affecting extremely premature infants who receive oxygen …
most common morbidities affecting extremely premature infants who receive oxygen …
TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension
FC Yeh, CN Chen, CY Xie, N Baxan… - European …, 2023 - Eur Respiratory Soc
Extract Growing evidence supports the contention that immune dysregulation and
autoimmunity predispose and contribute to the pathological remodelling that characterise …
autoimmunity predispose and contribute to the pathological remodelling that characterise …
[HTML][HTML] Artificial intelligence and cardiovascular risk prediction: all that glitters is not gold
Artificial intelligence (AI) is a broad term referring to any automated systems that need
'intelligence'to carry out specific tasks. During the last decade, AI-based techniques have …
'intelligence'to carry out specific tasks. During the last decade, AI-based techniques have …
Association study identified HLA‐DQA1 as a novel genetic risk of systemic lupus erythematosus‐associated pulmonary arterial hypertension
Objective Pulmonary arterial hypertension (PAH) is severe complication of systemic lupus
erythematosus (SLE). However, the genetic signatures of SLE‐associated PAH have not …
erythematosus (SLE). However, the genetic signatures of SLE‐associated PAH have not …
[HTML][HTML] The landscape of noncoding RNA in pulmonary hypertension
The transcriptome of pulmonary hypertension (PH) is complex and highly genetically
heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs …
heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs …
[HTML][HTML] An explorative metabolomic analysis of the endothelium in pulmonary hypertension
J Carlsen, HH Henriksen, I Marin de Mas… - Scientific reports, 2022 - nature.com
Pulmonary hypertension (PH) is classified into five clinical diagnostic groups, including
group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease …
group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease …