What drives the flow of signals controlling the outcome of post-transcriptional regulation of
gene expression? This regulatory layer, presiding to processes ranging from splicing to …

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair
and is associated with an increased risk of cancer,–. However, how such cycles affect the …

Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate
gene expression; however, their mechanisms of action remain poorly understood. Here, we …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a superfamily of RNA-binding
proteins consisting of more than 20 members. These proteins play a crucial role in various …

The zinc finger protein tristetraprolin (TTP) promotes translation repression and degradation
of mRNAs containing AU-rich elements (AREs). Although much attention has been directed …

Background Heterogeneous nuclear ribonucleoprotein F (hnRNP-F) has been implicated in
multiple cancers, suggesting its role in tumourigenesis, but the potential oncogenic role and …

The T cell-dependent (TD) antibody response involves the generation of high affinity,
immunoglobulin heavy chain class-switched antibodies that are generated through germinal …

Male subfertility or infertility is a common condition often characterized by men producing a
low number of sperm with poor quality. To gain insight into this condition, we performed a …

Post-transcriptional regulation of gene expression enables cells to fine-tune the expression
of a protein in a spatial and temporal manner. This regulation is mediated by the binding of …

The steady-state level of every mRNA expressed by a cell is governed by its rates of
synthesis and degradation. Synthetic rates principally reflect the rate of transcription, but in …