While there is consensus on starting urate-lowering therapy (ULT) in cases of symptomatic
hyperuricemia, the frequent condition of asymptomatic hyperuricemia (AH) remains a …

Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population
in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive …

Objectives Although beer and liquor have been associated with risk of incident gout, wine
has not. Yet anecdotally, wine is thought to trigger gout attacks. Further, how much alcohol …

Background: Gout is a common and debilitating condition that is associated with significant
morbidity and mortality. Despite advances in medical treatment, the global burden of gout …

New light has been shed on the mechanisms of action of colchicine in crystal-associated
arthropathies. Colchicine, long used to treat gout, arrests microtubule assembly and inhibits …

Background: Gout is a common type of inflammatory arthritis in patients seen by primary
care physicians. Purpose: To review evidence about treatment of acute gout attacks …

Introduction Hyperuricemia is a strong risk factor for gout. The incidence of gout and
hyperuricemia has increased recently, which is thought to be, in part, due to changes in diet …

Background Excess body burden of uric acid promotes gout. Diminished renal clearance of
uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter …

Objectives To determine whether gout increases risk of incident coronary heart disease
(CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of …

Objectives: To compare the efficacy and tolerability of allopurinol 300–600 mg/day versus
benzbromarone 100–200 mg/day used to attain a target serum urate concentration (sUr)⩽ …