Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Matrix-M™ adjuvant is a key component of several novel vaccine candidates. The Matrix-M
adjuvant consists of two distinct fractions of saponins purified from the Quillaja saponaria …

Germinal centres are the engines of antibody evolution. Here, using human
immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed …

To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry …

The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple
sclerosis has generated considerable interest in the development of an effective vaccine …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
monkeypox virus (MPXV) severely threaten human health; however, currently, no vaccine …

Germline-targeting immunogens hold promise for initiating the induction of broadly
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …

The lymphatic system has garnered significant attention in drug delivery research due to the
advantages it offers, such as enhancing systemic exposure and enabling lymph node …

Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this
work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic …

Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …