Sensory processing in autism spectrum disorders and Fragile X syndrome—From the clinic to animal models
Brains are constantly flooded with sensory information that needs to be filtered at the pre-
attentional level and integrated into endogenous activity in order to allow for detection of …
attentional level and integrated into endogenous activity in order to allow for detection of …
Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia
The lack of efficacy for antipsychotics with respect to negative symptoms and cognitive
deficits is a significant obstacle for the treatment of schizophrenia. Developing new drugs to …
deficits is a significant obstacle for the treatment of schizophrenia. Developing new drugs to …
Neurophysiological biomarkers for drug development in schizophrenia
DC Javitt, KM Spencer, GK Thaker, G Winterer… - Nature Reviews Drug …, 2008 - nature.com
Schizophrenia represents a pervasive deficit in brain function, leading to hallucinations and
delusions, social withdrawal and a decline in cognitive performance. As the underlying …
delusions, social withdrawal and a decline in cognitive performance. As the underlying …
Ketamine modulates theta and gamma oscillations
MT Lazarewicz, RS Ehrlichman, CR Maxwell… - Journal of cognitive …, 2010 - direct.mit.edu
Ketamine, an N-methyl-d-aspartate (NMDA) receptor glutamatergic antagonist, has been
studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies …
studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies …
Translating glutamate: from pathophysiology to treatment
DC Javitt, D Schoepp, PW Kalivas, ND Volkow… - Science translational …, 2011 - science.org
The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian
brain and is responsible for most corticocortical and corticofugal neurotransmission …
brain and is responsible for most corticocortical and corticofugal neurotransmission …
Deviance-elicited changes in event-related potentials are attenuated by ketamine in mice
RS Ehrlichman, CR Maxwell… - Journal of cognitive …, 2008 - ieeexplore.ieee.org
Background: People with schizophrenia exhibit reduced ability to detect change in the
auditory environment, which has been linked to abnormalities in N-methyl-D-aspartate …
auditory environment, which has been linked to abnormalities in N-methyl-D-aspartate …
Ketamine produces lasting disruptions in encoding of sensory stimuli
CR Maxwell, RS Ehrlichman, Y Liang, D Trief… - … of Pharmacology and …, 2006 - ASPET
The current study analyzed the acute, chronic, and lasting effects of ketamine administration
in four inbred mouse strains (C3H/HeHsd, C57BL/6Hsd, FVB/Hsd, and DBA/2Hsd) to …
in four inbred mouse strains (C3H/HeHsd, C57BL/6Hsd, FVB/Hsd, and DBA/2Hsd) to …
Knockout of NMDA receptors in parvalbumin interneurons recreates autism‐like phenotypes
JA Saunders, VM Tatard‐Leitman, J Suh… - Autism …, 2013 - Wiley Online Library
Autism is a disabling neurodevelopmental disorder characterized by social deficits,
language impairment, and repetitive behaviors with few effective treatments. New evidence …
language impairment, and repetitive behaviors with few effective treatments. New evidence …
Miniature neurologgers for flying pigeons: multichannel EEG and action and field potentials in combination with GPS recording
AL Vyssotski, AN Serkov, PM Itskov… - Journal of …, 2006 - journals.physiology.org
To study the neurophysiology of large-scale spatial cognition, we analyzed the neuronal
activity of navigating homing pigeons. This is not possible using conventional radio …
activity of navigating homing pigeons. This is not possible using conventional radio …
Animal models of schizophrenia
Schizophrenia may well represent one of the most heterogenous mental disorders in human
history. This heterogeneity encompasses (1) etiology; where numerous putative genetic and …
history. This heterogeneity encompasses (1) etiology; where numerous putative genetic and …