1, 2, 3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
K Bozorov, J Zhao, HA Aisa - Bioorganic & medicinal chemistry, 2019 - Elsevier
Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …
1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships
Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …
resistance associated with the currently used anticancer agents create an urgent need to …
1, 2, 3-Triazole-containing compounds as anti–lung cancer agents: Current developments, mechanisms of action, and structure–activity relationship
T Liang, X Sun, W Li, G Hou, F Gao - Frontiers in pharmacology, 2021 - frontiersin.org
Lung cancer is the most common malignancy and leads to around one-quarter of all cancer
deaths. Great advances have been achieved in the treatment of lung cancer with novel …
deaths. Great advances have been achieved in the treatment of lung cancer with novel …
Cyanoacetohydrazide linked to 1, 2, 3-triazole derivatives: A new class of α-glucosidase inhibitors
A Iraji, D Shareghi-Brojeni, S Mojtabavi… - Scientific Reports, 2022 - nature.com
In this work, a novel series of cyanoacetohydrazide linked to 1, 2, 3-triazoles (9a–n) were
designed and synthesized to be evaluated for their anti-α-glucosidase activity, focusing on …
designed and synthesized to be evaluated for their anti-α-glucosidase activity, focusing on …
Triazole based novel molecules as potential therapeutic agents: Synthesis, characterization, biological evaluation, in-silico ADME profiling and molecular docking …
In this study, eight new compounds (7a-h) based on triazole compounds containing ester
groups were synthesized with high yields. The structures of the synthesized compounds (7a …
groups were synthesized with high yields. The structures of the synthesized compounds (7a …
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Y Le, Y Gan, Y Fu, J Liu, W Li, X Zou… - Journal of enzyme …, 2020 - Taylor & Francis
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed,
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
An overview of recent advances in the applications of click chemistry in the synthesis of bioconjugates with anticancer activities
K Mashayekh, P Shiri - ChemistrySelect, 2019 - Wiley Online Library
The click chemistry is one of the most powerful C− N bond forming‐reactions towards five‐
membered heterocycles. The copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) has …
membered heterocycles. The copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) has …
1, 2, 3-triazole derivatives with anti-breast cancer potential
X Wu, J Wang, S Xia, S Cheng… - Current Topics in …, 2022 - ingentaconnect.com
Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …
of mortality among women across the world. Despite advances in chemotherapy, drug …
Identification and exploration of quinazoline-1, 2, 3-triazole inhibitors targeting EGFR in lung cancer
Epidermal growth factor receptor (EGFR) enhances lung cancer development, due to their
inability to permeate the cell membrane, secreted growth factors work through specialized …
inability to permeate the cell membrane, secreted growth factors work through specialized …
Visible light-mediated synthesis of quinazolinones from benzyl bromides and 2-aminobenzamides without using any photocatalyst or additive
S Huang, L Jin, Y Liu, G Yang, A Wang, Z Le… - Organic & …, 2024 - pubs.rsc.org
This paper reports a novel method for the visible-light-mediated synthesis of quinazolinones
from the reaction of benzyl bromides with 2-aminobenzamides. The reaction proceeded …
from the reaction of benzyl bromides with 2-aminobenzamides. The reaction proceeded …