Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Cancer contributes to 50% of deaths worldwide and new anti-tumour therapeutics with novel
mechanisms of actions are essential to develop. Metabolic inhibitors represent an important …

Next generation sequencing has enabled systematic discovery of mutational spectra in
cancer samples. Here, we used whole genome sequencing to characterize somatic …

The remarkable advances in the systemic therapy of metastatic melanoma have now
extended the 1-year overall survival rate from 25% to nearing 85%. Systemic treatment in …

Exosomes are 50–100 nm membranous vesicles actively released by cells which can be
indicative of a diseased cell status. They contain various kinds of molecule–proteins, mRNA …

Abstract SGN-CD228A is an investigational antibody–drug conjugate (ADC) directed to
melanotransferrin (CD228, MELTF, MFI2, p97), a cell-surface protein first identified in …

Brain metastases are a common feature of malignant melanoma and are associated with
poor prognosis. Melanotransferrin (MTf), one of several antigens associated with the surface …

Nitrogen monoxide (NO) is a vital effector and messenger molecule that plays roles in a
variety of biological processes. Many of the functions of NO are mediated by its high affinity …

BACKGROUND: Melanotransferrin was discovered in the 1980s as one of the first
melanoma tumour antigens. The molecule is a transferrin homologue that is found …

Aim: The aim of the study was to identify novel biomarkers that are vital for improving
management of patients with gastric cancer (GC). Materials and Methods: An RNA …