Immunosenescence: molecular mechanisms and diseases

Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Immunosenescence: a key player in cancer development

J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention

A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …

Update on anti-inflammatory molecular mechanisms induced by oleic acid

C Santa-María, S López-Enríquez… - Nutrients, 2023 - mdpi.com
In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural
Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high …

[HTML][HTML] Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept

HY Chung, DH Kim, EK Lee, KW Chung… - Aging and …, 2019 - ncbi.nlm.nih.gov
Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Natural killer cell dysfunction and its role in COVID-19

C van Eeden, L Khan, MS Osman… - International journal of …, 2020 - mdpi.com
When facing an acute viral infection, our immune systems need to function with finite
precision to enable the elimination of the pathogen, whilst protecting our bodies from …

Aging, melatonin, and the pro-and anti-inflammatory networks

R Hardeland - International journal of molecular sciences, 2019 - mdpi.com
Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

[HTML][HTML] From hepatitis A to E: A critical review of viral hepatitis

D Castaneda, AJ Gonzalez, M Alomari… - World journal of …, 2021 - ncbi.nlm.nih.gov
Viral infections affecting the liver have had an important impact on humanity, as they have
led to significant morbidity and mortality in patients with acute and chronic infections. Once …