Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

The basal ganglia are a subcortical collection of interacting clusters of cell bodies, and are
involved in reward, emotional, and motor circuits. Within all the brain processing necessary …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Striatal D2-type dopamine receptors (D2Rs) have been implicated in the pathophysiology of
neuropsychiatric disorders, including Parkinson's disease and schizophrenia. Although …

Dopamine D2 receptors (D2Rs) play a major role in the function of the prefrontal cortex
(PFC), and may contribute to prefrontal dysfunction in conditions such as schizophrenia …

By virtue of their large number, widespread distribution and important roles in cell
physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important …

Background Dysfunctional mesocorticolimbic dopamine signaling has been linked to
alterations in motor and reward-based functions associated with psychiatric disorders …

The mechanisms underlying modulation of corticostriatal synaptic transmission by D2-like
receptors (D2Rs) have been controversial. A recent study suggested that D2Rs inhibit …

Hematopoietic stem and progenitor cell (HSPC) function in bone marrow (BM) is controlled
by stroma-derived signals, but the identity and interplay of these signals remain incompletely …

Background The pathology of Parkinson's disease (PD) is characterized by the
degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of …