Summary α1-antitrypsin deficiency is a genetic disorder that affects about one in 2000–5000
individuals. It is clinically characterised by liver disease and early-onset emphysema …

Disease progression of chronic obstructive pulmonary disease (COPD) is variable, with
some patients having a relatively stable course, while others suffer relentless progression …

The purpose of this statement is to describe and define the phenotypic abnormalities that
can be identified on visual and quantitative evaluation of computed tomographic (CT) …

Rationale: The relative roles of mucus plugs and emphysema in mechanisms of airflow
limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) …

Background Pattern of emphysema at chest CT, scored visually by using the Fleischner
Society system, is associated with physiologic impairment and mortality risk. Purpose To …

Purpose To determine whether visually assessed patterns of emphysema at CT might
provide a simple assessment of mortality risk among cigarette smokers. Materials and …

Chronic obstructive pulmonary disease (COPD) exhibits significant heterogeneity in its
clinical presentation and rate of disease progression among affected individuals, owing at …

Rationale: Smoking-related microvascular loss causes end-organ damage in the kidneys,
heart, and brain. Basic research suggests a similar process in the lungs, but no large studies …

Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is
incompletely understood, although several genetic variants associated with COPD are …

Background Multiple studies have identified COPD subtypes by using visual or quantitative
evaluation of CT images. However, there has been no systematic assessment of a combined …