Metabolic alterations, driven by genetic and epigenetic factors, have long been known to be
associated with the etiology of cancer. Furthermore, accumulating evidence suggest that …

A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

Metabolome analysis is used to evaluate the characteristics and interactions of low
molecular weight metabolites under a specific set of conditions. In cirrhosis, hepatocellular …

Metformin is a commonly prescribed type II diabetes medication that exhibits promising
anticancer effects. Recently, these effects were found to be associated, at least in part, with a …

This review focuses on the evolving understanding that we have of tumor cell metabolism,
particularly glycolytic and oxidative metabolism, and traces back its evolution through time …

Background: Metabolomics plays an important role in providing insight into the etiology and
mechanisms of hepatocellular carcinoma (HCC). This is accomplished by a comprehensive …

Overcoming energy stress is a critical step for cells in solid tumors. Under this stress
microenvironment, cancer cells significantly alter their energy metabolism to maintain cell …

Background: Meis1 is a member of three-amino-acid loop extension (TALE) homeodomain
transcription factors. Studies in the last decade have shown that Meis1 has crucial roles in …

Gynaecological cancers are among the leading causes of cancer-related death among
women worldwide. Cancer cells undergo metabolic reprogramming to sustain the …

Due to the physiological complexity of the tumour, a single drug therapeutic strategy may not
be sufficient for effective treatment. Emerging evidence suggests that combination strategies …