Vaccine Formulation Strategies and Challenges Involved in RNA Delivery for Modulating Biomarkers of Cardiovascular Diseases: A Race from Laboratory to Market
It has been demonstrated that noncoding RNAs have significant physiological and
pathological roles. Modulation of noncoding RNAs may offer therapeutic approaches as per …
pathological roles. Modulation of noncoding RNAs may offer therapeutic approaches as per …
[HTML][HTML] Safety and effectiveness of interference RNA (RNAi) based therapeutics in cardiac failure: A systematic review
MN Saddique, M Qadri, N ul Ain, E Farhan, F Shahid… - Heart & Lung, 2024 - Elsevier
Background Heart failure is a major worldwide health concern and leading cause of
mortality. RNAi interventions hold promise for patients resistant to conventional drugs due to …
mortality. RNAi interventions hold promise for patients resistant to conventional drugs due to …
Drug development for major chronic health conditions—aligning with growing public health needs: Proceedings from a multistakeholder think tank
KA Krychtiuk, TLG Andersson, U Bodesheim… - American Heart …, 2024 - Elsevier
The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases
due to more predictable development pathways and financial incentives. In contrast, drug …
due to more predictable development pathways and financial incentives. In contrast, drug …
siRNA as potential therapeutic strategy for hypertension
Hypertension, a well-known cardiovascular disorder noticed by rise in blood pressure,
poses a significant global health challenge. The development RNA interfering (RNAi)-based …
poses a significant global health challenge. The development RNA interfering (RNAi)-based …
The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
Metabolic syndrome (MetS) is a prevalent and intricate health condition affecting a
significant global population, characterized by a cluster of metabolic and hormonal disorders …
significant global population, characterized by a cluster of metabolic and hormonal disorders …
Bioanalysis of free antisense oligonucleotide payload from antibody–oligonucleotide conjugate by hybridization LC-MS/MS
Background: Antisense oligonucleotides (ASOs) have been conjugated to various moieties,
such as peptides, antibodies or Fab regions of antibodies, to enhance their delivery to target …
such as peptides, antibodies or Fab regions of antibodies, to enhance their delivery to target …
The year in cardiovascular pharmacotherapy 2022: landmark evidence at a glance
There have been major advances in cardiovascular pharmacotherapy in recent decades,
but many evidence gaps remain. Our patients have high expectations of cardiology research …
but many evidence gaps remain. Our patients have high expectations of cardiology research …