[HTML][HTML] Peptide-drug conjugates: a new hope for cancer management
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …
options for patients. As such, safe and effective therapeutics are required. Short peptides …
[HTML][HTML] Precision-engineering of subunit vaccine particles for prevention of infectious diseases
Vaccines remain the best approach for the prevention of infectious diseases. Protein subunit
vaccines are safe compared to live-attenuated whole cell vaccines but often show reduced …
vaccines are safe compared to live-attenuated whole cell vaccines but often show reduced …
[HTML][HTML] Peptide mediated therapy in fibrosis: Mechanisms, advances and prospects
X Ye, J Li, Z Liu, X Sun, D Wei, L Song, C Wu - Biomedicine & …, 2023 - Elsevier
Fibrosis, a disease characterized by an excess accumulation of extracellular matrix
components, could lead to organ failure and death, and is to blame for up to 45% of all …
components, could lead to organ failure and death, and is to blame for up to 45% of all …
[HTML][HTML] Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides
Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …
separate cells from their neighborhood to allow for a controlled composition of the …
A cationic lipid with advanced membrane fusion performance for pDNA and mRNA delivery
Y Wei, T He, Q Bi, H Yang, X Hu, R Jin… - Journal of Materials …, 2023 - pubs.rsc.org
The success of mRNA vaccines for COVID-19 prevention raised global awareness of the
importance of nucleic acid drugs. The approved systems for nucleic acid delivery were …
importance of nucleic acid drugs. The approved systems for nucleic acid delivery were …
Absorption of egg white hydrolysate in the intestine: clathrin-dependent endocytosis as the main transport route
H You, J Li, Y Li, W Wang, Z Yu, J Liu, X Liu… - Food Research …, 2023 - Elsevier
This paper aimed to investigate the in vivo absorption of egg white hydrolysate (EWH) in rats
and the transport route across the intestinal epithelium. Results showed that the level of …
and the transport route across the intestinal epithelium. Results showed that the level of …
Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications
A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …
remarkable ability to cross cell membranes and deliver various types of cargoes, including …
Leaflet-dependent effect of anionic lipids on membrane insertion by cationic cell-penetrating peptides
SC Povilaitis, LJ Webb - The journal of physical chemistry letters, 2023 - ACS Publications
Cationic membrane-permeating peptides can cross membranes unassisted by
transmembrane protein machinery, and there is consensus that anionic lipids facilitate this …
transmembrane protein machinery, and there is consensus that anionic lipids facilitate this …
[HTML][HTML] Enhancing the Antimicrobial Properties of Peptides through Cell-Penetrating Peptide Conjugation: A Comprehensive Assessment
SV Kravchenko, PA Domnin, SY Grishin… - International Journal of …, 2023 - mdpi.com
Combining antimicrobial peptides (AMPs) with cell-penetrating peptides (CPPs) has shown
promise in boosting antimicrobial potency, especially against Gram-negative bacteria. We …
promise in boosting antimicrobial potency, especially against Gram-negative bacteria. We …
[HTML][HTML] Cationic Materials for Gene Therapy: A Look Back to the Birth and Development of 2, 2-Bis-(hydroxymethyl) Propanoic Acid-Based Dendrimer Scaffolds
S Alfei - International Journal of Molecular Sciences, 2023 - mdpi.com
Gene therapy is extensively studied as a realistic and promising therapeutic approach for
treating inherited and acquired diseases by repairing defective genes through introducing …
treating inherited and acquired diseases by repairing defective genes through introducing …