Abstract 3-[(2-Chloroquinolin-3-yl) methylene]-5-phenylfuran-2 (3H)-one derivatives (6a–j
and 7a–j) have been synthesized and evaluated for their antimalarial activity. Three …

Emergence and spread of drug-resistant falciparum malaria has created an urgent demand
for alternative therapeutic agents. This study was conducted to assess the in vitro blood …

Malaria has developed as a serious worldwide health issue as a result of the introduction of
resistant Plasmodium species strains. Because of the common chemo resistance to most of …

Increases in international travel and escalating drug resistance have resulted in a growing
number of travelers at risk of contracting malaria. Drug resistance and intolerance to …

Background Malaria causes repeated illness in children living in endemic areas. Policies of
giving antimalarial drugs at regular intervals (prophylaxis or intermittent treatment) are being …

Background/Aims: The 8-aminoquinoline tafenoquine has been shown to be effective
against Plasmodia, Leishmania and Trypanosoma. The substance is at least in part effective …

We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen
of tafenoquine to determine whether these concentrations adequately suppressed malarial …

A facile transition metal-free decarboxylative C4 selective C–H difluoroarylmethylation of 8-
aminoquinolines under simple aqueous conditions has been developed. It provides a novel …

A randomized, double-blind, placebo-controlled study was conducted to assess the effect of
tafenoquine, 200 mg weekly for 6 months on ophthalmic and renal safety. This trial was …

Currently available medications for malaria chemoprophylaxis are efficacious but the
problems of patient compliance, the advance of parasite drug resistance, and real or …