Abstract 3-[(2-Chloroquinolin-3-yl) methylene]-5-phenylfuran-2 (3H)-one derivatives (6a–j
and 7a–j) have been synthesized and evaluated for their antimalarial activity. Three …

Aminoquinolines are an important class of antimalarial drugs because they are effective
against the liver stages of Plasmodium infections and thus are administered for radical cure …

Malaria causes significant morbidity and mortality in travelers. One barrier to effective
prevention of malaria in travelers is poor adherence to recommended chemoprophylaxis …

The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking
tafenoquine for malarial prophylaxis. The subjects (476 males and 14 females) received a …

Malaria, an infectious disease caused by Plasmodium spp, is one of the world's most
dangerous diseases, accounting for more than half a million deaths yearly. The long years of …

Background Chemoprophylaxis with weekly doses of tafenoquine (200 mg/day for 3 days
before departure [loading dose], 200 mg/week during travel and 1-week post-travel …

Introduction: Malaria remains one of the most important infectious diseases, causing around
655 000 deaths annually, mostly among children in Sub-Saharan Africa. Plasmodium …

Eukaryotic pathogens typically follow a complex life cycle, including host switch and
morphologically distinct forms. Parasite stage conversion offers exceptional opportunities for …

Background Plasmodium vivax malaria has a persistent liver stage that causes relapse of
the disease and continued P vivax transmission. Primaquine (PQ) is used to clear the liver …

A simple and efficient copper-catalyzed monofluoromethylation of 8-aminoquinolines with 2-
bromo-2-fluoroacetate has been described with HPO (OMe) 2 (dimethyl phosphonate) as …