The introduction of fluorine in drug-like compounds is now a well-accepted and very efficient
strategy in drug discovery, encouraged by the extensive synthetic methodologies available …

A new 8-aminoquinoline antimalarial WR 238605 (Tafenoquine), developed initially as a
primaquine alternative for prevention of Plasmodiumvivax relapses was evaluated for blood …

A metal and light‐free Minisci‐type acylation approach of 8‐aminoquinoline amides with
general primary alcohols was demonstrated under tBu4NCl/K2S2O8 system …

Malaria is of continuing concern in nonimmune traveling populations. Traditionally,
antimalarial drugs have been developed as agents for dual indications (treatment and …

A simple and efficient copper-catalyzed monofluoromethylation of 8-aminoquinolines with 2-
bromo-2-fluoroacetate has been described with HPO (OMe) 2 (dimethyl phosphonate) as …

Plasmodium falciparum gametocytes are not associated with clinical symptoms, but they are
responsible for transmitting the pathogen to mosquitoes. Therefore, gametocytocidal …

A recent publication has shown that primaquine, a drug used to clear liver-stage
Plasmodium vivax infection, acts as a chloroquine-resistance reversing agent for …

Background Chemoprophylaxis with weekly doses of tafenoquine (200 mg/day for 3 days
before departure [loading dose], 200 mg/week during travel and 1-week post-travel …

Introduction: The development of new antimalarial drugs remains of the utmost importance,
since Plasmodium falciparum has developed resistance against nearly all …

The ultimate aim of malaria chemotherapy is not only to treat symptomatic infection but also
to reduce transmission potential. With the absence of clinically proven vaccines, drug …