Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …

Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …

Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Ageing causes loss of function in tissues and organs, is accompanied by a chronic
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …

Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely
associated with a state of low-grade inflammation,. In adipose tissue chronic overnutrition …

This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …

AMP-activated protein kinase (AMPK) β1 or β2 subunits are required for assembling of
AMPK heterotrimers and are important for regulating enzyme activity and cellular …