[HTML][HTML] Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk
Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …
Regulation of mitochondrial biogenesis
FR Jornayvaz, GI Shulman - Essays in biochemistry, 2010 - portlandpress.com
Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …
muscle, the molecular mechanisms underlying this process have only recently been …
Adiponectin: mechanistic insights and clinical implications
AT Turer, PE Scherer - Diabetologia, 2012 - Springer
Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
MD Hirschey, T Shimazu, E Jing, CA Grueter… - Molecular cell, 2011 - cell.com
Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …
protein modification, yet the metabolic consequence of mitochondrial protein …
AMPK in health and disease
GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
RA DeFronzo - Diabetologia, 2010 - Springer
Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
Calorie restriction as an intervention in ageing
G López‐Lluch, P Navas - The Journal of physiology, 2016 - Wiley Online Library
Ageing causes loss of function in tissues and organs, is accompanied by a chronic
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
JI Odegaard, RR Ricardo-Gonzalez, MH Goforth… - Nature, 2007 - nature.com
Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely
associated with a state of low-grade inflammation,. In adipose tissue chronic overnutrition …
associated with a state of low-grade inflammation,. In adipose tissue chronic overnutrition …
Mechanisms of vascular aging: new perspectives
This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …
vasculature during aging; explores the links between mitochondrial oxidative stress …
AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during …
HM O'Neill, SJ Maarbjerg, JD Crane… - Proceedings of the …, 2011 - National Acad Sciences
AMP-activated protein kinase (AMPK) β1 or β2 subunits are required for assembling of
AMPK heterotrimers and are important for regulating enzyme activity and cellular …
AMPK heterotrimers and are important for regulating enzyme activity and cellular …