Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …

As resident component of the innate immunity in the central nervous system (CNS),
microglia are key players in pathology. However, they also exert fundamental roles in brain …

Background Brain injury is the main cause of poor prognosis in heatstroke (HS) patients due
to heat-stress-induced neuronal apoptosis. However, as a new cross-talk way among cells …

Recent evidence pinpoints extracellular vesicles (EVs) as key players in intercellular
communication. Given the importance of cholesterol and sphingomyelin in EV biology, and …

Adenovirus (Ad) is a major causal agent of acute respiratory infections. However, they are a
powerful delivery system for gene therapy and vaccines. Some Ad serotypes antagonize the …

Cocaine use disorder has been reported to cause transgenerational effects. However, due
to the lack of standardized biomarkers, the effects of cocaine use during pregnancy on …

In multiple neurodevelopmental and neurodegenerative disorders, endosomal changes
correlate with changes in exosomes. We examined this linkage in the brain of mice that …

Background Microglia are important myeloid cells present in the brain parenchyma that
serve a surveillance function in the central nervous system. Microglial cell activation results …

Hepatocellular carcinoma (HCC) is the third most common cancer worldwide, and invasion
and metastasis are the leading causes of death. Astragaloside IV (AS‐IV), a kind of …

CD81, a member of the tetraspanin family, plays important roles in many physiological
processes, such as cell motility, attachment, and entry. Yet, CD81 functions in the brain …