Anaplastic thyroid carcinoma: an update

A Jannin, A Escande, A Al Ghuzlan, P Blanchard… - Cancers, 2022 - mdpi.com
Simple Summary Anaplastic thyroid carcinoma (ATC) has a dismal prognostic.
Chemotherapy and radiotherapy are the mainstem options for patients with ATC. In selected …

Molecular pathology of poorly differentiated and anaplastic thyroid cancer: what do pathologists need to know?

M Volante, AK Lam, M Papotti, G Tallini - Endocrine pathology, 2021 - Springer
The molecular characterization of poorly and anaplastic thyroid carcinomas has been
greatly improved in the last years following the advent of high throughput technologies …

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes

R Gao, S Bai, YC Henderson, Y Lin, A Schalck… - Nature …, 2021 - nature.com
Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …

Dissecting anaplastic thyroid carcinoma: a comprehensive clinical, histologic, immunophenotypic, and molecular study of 360 cases

B Xu, T Fuchs, S Dogan, I Landa, N Katabi, JA Fagin… - Thyroid, 2020 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) is nearly always fatal. Large studies on
ATC are exceedingly rare. We aimed to study the clinical, genotypic, and histologic …

The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy

A Singh, J Ham, JW Po, N Niles, T Roberts, CS Lee - Cells, 2021 - mdpi.com
Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …

Anaplastic thyroid carcinoma: Current issues in genomics and therapeutics

I Abe, AK Lam - Current Oncology Reports, 2021 - Springer
Abstract Purpose of Review Anaplastic thyroid carcinoma is a type of thyroid carcinoma with
the most aggressive biological behaviour amongst thyroid cancer. Here, we review the …

Molecular features of aggressive thyroid cancer

G Elia, A Patrizio, F Ragusa, SR Paparo… - Frontiers in …, 2022 - frontiersin.org
Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) have a
worse prognosis with respect to well differentiated TC, and the loss of the capability of up …

Novel recurrent altered genes in Chinese patients with anaplastic thyroid cancer

L Zhang, Z Ren, Z Su, Y Liu, T Yang… - The Journal of …, 2021 - academic.oup.com
Background Anaplastic thyroid cancer (ATC) is a rare but lethal malignancy, and few
systematic investigations on genomic profiles of ATC have been performed in Chinese …

Pan-Genomic Sequencing Reveals Actionable CDKN2A/2B Deletions and Kataegis in Anaplastic Thyroid Carcinoma

A Stenman, M Yang, JO Paulsson, J Zedenius… - Cancers, 2021 - mdpi.com
Simple Summary Anaplastic thyroid carcinoma (ATC) is a tumor with exceedingly high
mortality rates, and current treatment options are very limited once the disease has spread …

Advances in thyroid pathology: high grade follicular cell-derived thyroid carcinoma and anaplastic thyroid carcinoma

B Xu, RA Ghossein - Advances in Anatomic Pathology, 2023 - journals.lww.com
Abstract In the upcoming World Health Organization fifth edition classification of endocrine
tumors, there were several major changes related to high grade follicular-derived thyroid …