The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

In many aspects, the immune response against pathogens in insects is similar to the innate
immunity in mammals. This has caused a strong interest in the scientific community for the …

Staphylococcus aureus is a Gram-positive bacterium that has become the leading cause of
hospital acquired infections in the US. Repurposing Food and Drug Administration (FDA) …

Galleria mellonella is a well-accepted insect model for the study of pathogen-host
interactions and antimicrobial compounds. The main advantages of this model include the …

Background: Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and
requires prolonged treatment; therefore, new therapeutic approaches are necessary. In view …

In the past decade, Galleria mellonella (wax moth) larvae have become widely used as a
non-mammalian infection model. However, the full potential of this infection model has yet to …

Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

Paracoccidioides brasiliensis and P. lutzii are etiologic agents of paracoccidioidomycosis
(PCM), an important endemic mycosis in Latin America. During its evolution, these fungi …

Silkworm, Bombyx mori, has various advantages as an experimental animal, such as the low
cost for rearing and fewer ethical problems. Models utilizing silkworms of infection with …

The pathogenic species of Cryptococcus are a major cause of mortality owing to severe
infections in immunocompromised as well as immunocompetent individuals. Although …