Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Despite the tremendous amount of data over the last 40years, lack of gap junctional
intercellular communication (GJIC) or altered expression of gap junction proteins is still a …

Abstract Background Connexin 43 (Cx43), the most widely expressed gap junction protein,
is associated with a number of physiological and pathological conditions. Many functions of …

Gap junction (GJ) channels and their connexins (Cxs) are complex proteins that have
essential functions in cell communication processes in the central nervous system (CNS) …

Connexin 43 (Cx43) is a gap junction protein that assembles at the cell border to form
intercellular gap junction (GJ) channels which allow for cell–cell communication by …

Precise diagnosis of low and high grades of brain tumors permits determining therapeutical
strategies. So far, diagnosis and prognosis of gliomas were based on histological and …

Direct intercellular communication, mediated by gap junctions formed by the connexin
transmembrane protein family, is frequently dysregulated in cancer. Connexins have been …

The availability of intracellular, stabilized β-catenin, a transcription factor coactivator, is
tightly regulated; β-catenin is translocated into the nucleus in response to Wnt ligand binding …