Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel
Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial …

Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore,
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …

Neurotransmitters play essential roles in regulating neural circuit dynamics both in the
central nervous system as well as at the peripheral, including the gastrointestinal tract …

Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …

Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases
(IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut …

Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …

Inflammatory bowel diseases (IBDs) develop as a result of complex interactions among
genes, innate immunity and environmental factors, which are related to the gut microbiota …

Intestinal immune homeostasis and microbiome structure play a critical role in the
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel
disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is …